Longitudinal and Cross-sectional Analyses of Lung Function in Toluene Diisocyanate Production Workers. J Occup Environ Med 2017 Dec;59 Suppl 12(Suppl 12):S28-S35
Date
12/05/2017Pubmed ID
29200136Pubmed Central ID
PMC5763545DOI
10.1097/JOM.0000000000001124Scopus ID
2-s2.0-85036649578 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
OBJECTIVE: The aim of this study was to investigate lung function among toluene diisocyanate (TDI) production workers.
METHODS: One hundred ninety-seven U.S workers performed spirometry from 2006 through 2012. Results were compared within the study cohort and with U.S. population measures. A mixed-effects model assessed factors affecting repeated forced expiratory volume in 1 second (FEV1) measurements.
RESULTS: The cohort's mean FEV1 and forced vital capacity (FVC) percent reference values, although greater than 90%, were significantly lower and the prevalence of abnormal spirometry (predominantly restrictive pattern) was significantly higher than in the U.S.
POPULATION: Differences in lung function among workers with higher cumulative TDI exposure were in the direction of an exposure effect, but not significant.
CONCLUSION: We found little evidence of an adverse effect of TDI exposure on longitudinal spirometry in these workers. The association between TDI exposure and the increasing prevalence of a restrictive pattern needs further exploration.
Author List
Wang ML, Storey E, Cassidy LD, Doney B, Conner PR, Collins JJ, Carson M, Molenaar DAuthor
Laura Cassidy PhD Associate Dean, Professor in the Institute for Health and Equity department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAge Factors
Aged
Body Mass Index
Body Weight
Chemical Industry
Cross-Sectional Studies
Female
Forced Expiratory Volume
Humans
Longitudinal Studies
Male
Middle Aged
Occupational Exposure
Spirometry
Toluene 2,4-Diisocyanate
Vital Capacity
Young Adult
