The importance of the circadian system & sleep for bone health. Metabolism 2018 Jul;84:28-43
Date
12/13/2017Pubmed ID
29229227Pubmed Central ID
PMC5994176DOI
10.1016/j.metabol.2017.12.002Scopus ID
2-s2.0-85040451185 (requires institutional sign-in at Scopus site) 84 CitationsAbstract
Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.
Author List
Swanson CM, Kohrt WM, Buxton OM, Everson CA, Wright KP Jr, Orwoll ES, Shea SAAuthor
Carol A. Everson PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBone Density
Bone and Bones
Circadian Clocks
Circadian Rhythm
Health
Humans
Sleep
Sleep Deprivation
