Autism Spectrum Symptomatology Among Children with Duplication 7q11.23 Syndrome. J Autism Dev Disord 2018 Jun;48(6):1982-1994
Date
01/08/2018Pubmed ID
29307037Pubmed Central ID
PMC6003247DOI
10.1007/s10803-017-3439-zScopus ID
2-s2.0-85040043831 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
Gold-standard diagnostic assessments of autism spectrum disorder (ASD) symptomatology were conducted on 63 children (mean CA: 8.81 years) with 7q11.23 duplication syndrome, one of the copy number variants identified by Sanders et al. (Neuron 70:863-885, 2011a) as associated with ASD. ASD classification rate was 39.6% for the Autism Diagnostic Interview-Revised and 25.4% for the Autism Diagnostic Observation Schedule-2 (ADOS-2). Based on these assessments combined with clinical judgment, 19.0% of children were diagnosed with ASD. Reasons for these discrepancies are discussed, as are differences in rate of diagnosis as a function of sex, age, and ADOS-2 module administered and differences in intellectual and adaptive behavior abilities as a function of presence or absence of ASD diagnosis and ADOS-2 module administered. Implications are addressed.
Author List
Klein-Tasman BP, Mervis CBAuthor
Bonita Klein-Tasman BA,MA,PhD Professor in the Psychology department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
Adaptation, PsychologicalAdolescent
Autism Spectrum Disorder
Child
Child, Preschool
Cross-Sectional Studies
Female
Humans
Male
Surveys and Questionnaires
Williams Syndrome
