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The influence of the analysis technique on estimating liver iron overload using magnetic resonance imaging T2* quantification. Annu Int Conf IEEE Eng Med Biol Soc 2014;2014:4639-42



Pubmed ID




Scopus ID

2-s2.0-84929497667   1 Citation


Iron toxicity is the major cause of tissue damage in patients with iron overload. Iron deposits mainly in the liver, where its concentration closely correlates with whole body iron overload. Different techniques have been proposed for estimating iron content, with liver biopsy being the gold standard despite its invasiveness and influence by sampling error. Recently, magnetic resonance imaging (MRI) has been established as an effective technique for evaluating iron overload by measuring T2(*) in the liver. However, various factors associated with the adopted analysis technique, mainly the exponential fitting model and signal averaging method, affect the resulting measurements. In this study, we evaluate the influences of these factors on T2(*) measurement in numerical phantom, calibrated phantoms, and nine patients with different degrees of iron overload. The results show different performances among the fitting models and signal averaging methods, which are affected by SNR, image quality and signal homogeneity inside the selected ROI for analysis.

Author List

Ibrahim el-SH, Khalifa AM, Eldaly AK


El-Sayed H. Ibrahim PhD Associate Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Image Processing, Computer-Assisted
Iron Overload
Magnetic Resonance Imaging
Phantoms, Imaging