Faculty Collaboration Database

Allergic reaction to latex: a risk factor for unsuspected anaphylaxis. Allergy Proc 1991;12(2):95-102

Date

03/01/1991

Pubmed ID

2060787

DOI

10.2500/108854191779011846

Scopus ID

2-s2.0-0025727360 (requires institutional sign-in at Scopus site)   41 Citations

Abstract

Allergic reactions to latex, including anaphylaxis may be a problem in certain individuals exposed to latex. Four atopic patients with symptoms of rhinitis, asthma, anaphylaxis, and/or urticaria upon contact with latex products were studied. The patients showed IgE binding to latex RAST disks ranging from 1.0 to 27.3 times the negative control. Latex products (gloves, balloons, and condoms) directly bound IgE from all four patients. Eluted proteins from the latex products inhibited IgE binding to commercial latex RAST disks. SDS-PAGE demonstrated multiple latex protein bands by Coomassie Blue staining between 14 and 66 kD. Immunoblotting showed specific IgE binding to latex proteins at 30 and 66 kD. These results indicate that latex-allergic patients have IgE directed against specific latex proteins. Allergy to latex can pose a substantial health risk to susceptible individuals.

Author List

Warpinski JR, Folgert J, Cohen M, Bush RK

Author

James R. Warpinski MD Adjunct Assistant Professor in the Medical School Regional Campuses department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Anaphylaxis
Child
Dermatitis, Atopic
Humans
Hypersensitivity
Immunoblotting
Latex
Male
Radioallergosorbent Test
Respiratory Hypersensitivity
Risk Factors