Severity, course, and predictors of sleep disruption following hematopoietic cell transplantation: a secondary data analysis from the BMT CTN 0902 trial. Bone Marrow Transplant 2018 Aug;53(8):1038-1043
Date
03/09/2018Pubmed ID
29515249Pubmed Central ID
PMC6064383DOI
10.1038/s41409-018-0138-0Scopus ID
2-s2.0-85042913895 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Sleep disruption has received little attention in hematopoietic cell transplantation (HCT). The goal of this study was to describe severity, course, and predictors of sleep disruption following HCT. A secondary data analysis was conducted of the Blood and Marrow Transplantation Clinical Trials Network (BMT CTN) 0902 study. Participants completed a modified version of the Pittsburgh Sleep Quality Index prior to transplant and 100 and 180 days posttransplant. Growth mixture models were used to characterize subgroups of patients based on baseline sleep disruption and change over time. A total of 570 patients (mean age 55 years, 42% female) were included in the current analyses. Patients could be grouped into four distinct classes based on sleep disruption: (1) clinically significant sleep disruption at baseline that did not improve over time (20%); (2) clinically significant sleep disruption at baseline that improved over time (22%); (3) sleep disruption that did not reach clinical significance at baseline and did not improve over time (45%); and (4) no sleep disruption at baseline or over time (13%). These data provide a more comprehensive understanding of sleep disruption that can be used to develop interventions to improve sleep in HCT recipients.
Author List
Jim HSL, Sutton S, Majhail NS, Wood WA, Jacobsen PB, Wingard JR, Wu J, Knight JM, Syrjala KL, Lee SJAuthor
Jennifer M. Knight MD, MS Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
FemaleHematopoietic Stem Cell Transplantation
Humans
Male
Middle Aged
Quality of Life
Sleep Wake Disorders
Transplantation Conditioning
