Outcomes after testicular aspiration and testicular tissue cryopreservation for obstructive azoospermia and ejaculatory dysfunction. J Urol 2008 Dec;180(6):2577-80
Date
10/28/2008Pubmed ID
18950806DOI
10.1016/j.juro.2008.08.034Scopus ID
2-s2.0-55549124833 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
PURPOSE: We examined the rate of successful sperm retrieval, fertilization, pregnancy and live births in patients with obstructive azoospermia and ejaculatory dysfunction who underwent testicular sperm aspiration in conjunction with in vitro fertilization/intracytoplasmic sperm injection using cryopreserved testicular tissue.
MATERIALS AND METHODS: We retrospectively reviewed the records of 40 couples who underwent testicular sperm aspiration from August 2003 to November 2007. All procedures were performed before intracytoplasmic sperm injection with the goal of tissue cryopreservation.
RESULTS: Mature sperm was successfully retrieved and cryopreserved in 39 of 40 patients (97%) with an average of 5 vials cryopreserved per couple. Of the women 34 underwent in vitro fertilization/intracytoplasmic sperm injection and in 5 treatment was planned. The fertilization rate was 58% with a pregnancy rate of 61.4% (27 of 44 cycles). There were 17 live births, 5 ongoing pregnancies and 5 miscarriages. No complications were noted and all patients returned to full activity within 2 to 3 days.
CONCLUSIONS: Testicular sperm aspiration with cryopreservation is a safe and effective sperm retrieval method in patients with obstructive azoospermia and ejaculatory dysfunction when in vitro fertilization/intracytoplasmic sperm injection will be performed.
Author List
Garg T, LaRosa C, Strawn E, Robb P, Sandlow JIAuthor
Jay I. Sandlow MD Chair, Professor in the Urologic Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAzoospermia
Cryopreservation
Ejaculation
Female
Humans
Male
Middle Aged
Pregnancy
Retrospective Studies
Sexual Dysfunction, Physiological
Sperm Retrieval
Testis
Treatment Outcome
