Faculty Collaboration Database

Secretory carcinoma of the parotid with adenoid cystic carcinoma cytological pattern: A cytological-pathological correlation with literature review. Ann Diagn Pathol 2018 Apr;33:58-61

Date

03/24/2018

Pubmed ID

29566949

DOI

10.1016/j.anndiagpath.2017.12.006

Scopus ID

2-s2.0-85039718573 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

Secretory carcinoma (SC) is a rare low-grade malignant tumor, defined by ETV6-NTRK3 fusion, identifiable by FISH. We describe a case in a 58-year-old male with a painless slowly growing 16mm palpable mass within left superficial parotid. FNA of the mass showed highly cellular specimen with moderate to large pleomorphic cells with round to ovoid nuclei with vesicular chromatin and distinct nucleoli. Cells had moderate to large amounts of vacuolated cytoplasm. Abundant globular metachromatic material, resembling that of adenoid cystic carcinoma, was noted. This material was seen extracellularly and intracytoplasmic, and stained magenta on Diff-Quik and blue-green on Papanicolaou-stained slides. The tumor cells on a cell block preparation were positive for Mammaglobin and S-100. PAS stain highlighted extracellular and intracytoplasmic secretions. FNA diagnosis was "Positive for Malignancy. Morphologic features most compatible with Mammary Analogue Secretory Carcinoma". ETV6 FISH studies as well as histologic examination of excised tumor confirmed the diagnosis. Finding the globular metachromatic material in SC, that is generally seen in adenoid cystic carcinoma, broadens a cytological differential diagnosis of both entities. Cytological differential diagnosis, clinical, histological, immunohistochemical, and molecular features of secretory carcinomas are discussed in this study.

Author List

Kravtsov O, Hunt B, Peterson J, Carrillo L, Bonneau P, Giorgadze T

Author

Bryan C. Hunt MD Associate Professor in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Biomarkers, Tumor
Breast Neoplasms
Carcinoma
Carcinoma, Adenoid Cystic
Carcinoma, Mucoepidermoid
Diagnosis, Differential
Humans
Male
Mammary Analogue Secretory Carcinoma
Middle Aged