Feasibility of conducting long-term follow-up of children and infants treated for CNS tumors on the same cooperative group clinical trial protocol. J Clin Psychol Med Settings 2014 Jun;21(2):136-43
Date
03/29/2014Pubmed ID
24668336Pubmed Central ID
PMC5140088DOI
10.1007/s10880-014-9391-6Scopus ID
2-s2.0-84902318153 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Given the barriers to conducting long-term assessment of neurocognitive and psychosocial functioning of those treated in infancy for central nervous system (CNS) tumors, a multi-site feasibility study was conducted. The primary objective was to demonstrate that it is feasible to identify, locate and assess the functioning of children treated on the same protocol 10-years post-treatment. Six sites obtained institutional approval, identified and recruited subjects, and obtained comprehensive neurocognitive and psychosocial data. All feasibility objectives were met. Barriers to participation included length of time for Institutional Review Board submission and review, clinical demands, limited eligible participants at individual institutions, difficulty locating long-term subjects and stipend/reimbursement concerns. Results indicate that long-term studies are feasible and essential given the need to address long-term issues of children treated at a young age for CNS tumors, especially as they relate to later academic and vocational planning, but require significant coordination and commitment of cooperative group and institutional resources.
Author List
Hoag J, Kupst MJ, Briere ME, Mabbott D, Elkin TD, Trask CL, Isenberg J, Holm S, Ambler C, Strother DRAuthor
Jennifer A. Hoag PhD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentCentral Nervous System Neoplasms
Child
Child, Preschool
Clinical Trials as Topic
Cooperative Behavior
Data Collection
Educational Status
Executive Function
Feasibility Studies
Female
Follow-Up Studies
Health Status
Humans
Infant
Infant, Newborn
Intelligence
Male
Memory
Mental Health
Mental Processes
Patient Compliance
Treatment Outcome
