Medical College of Wisconsin
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Feasibility of conducting long-term follow-up of children and infants treated for CNS tumors on the same cooperative group clinical trial protocol. J Clin Psychol Med Settings 2014 Jun;21(2):136-43

Date

03/29/2014

Pubmed ID

24668336

Pubmed Central ID

PMC5140088

DOI

10.1007/s10880-014-9391-6

Scopus ID

2-s2.0-84902318153   1 Citation

Abstract

Given the barriers to conducting long-term assessment of neurocognitive and psychosocial functioning of those treated in infancy for central nervous system (CNS) tumors, a multi-site feasibility study was conducted. The primary objective was to demonstrate that it is feasible to identify, locate and assess the functioning of children treated on the same protocol 10-years post-treatment. Six sites obtained institutional approval, identified and recruited subjects, and obtained comprehensive neurocognitive and psychosocial data. All feasibility objectives were met. Barriers to participation included length of time for Institutional Review Board submission and review, clinical demands, limited eligible participants at individual institutions, difficulty locating long-term subjects and stipend/reimbursement concerns. Results indicate that long-term studies are feasible and essential given the need to address long-term issues of children treated at a young age for CNS tumors, especially as they relate to later academic and vocational planning, but require significant coordination and commitment of cooperative group and institutional resources.

Author List

Hoag J, Kupst MJ, Briere ME, Mabbott D, Elkin TD, Trask CL, Isenberg J, Holm S, Ambler C, Strother DR

Author

Jennifer A. Hoag PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Central Nervous System Neoplasms
Child
Child, Preschool
Clinical Trials as Topic
Cooperative Behavior
Data Collection
Educational Status
Executive Function
Feasibility Studies
Female
Follow-Up Studies
Health Status
Humans
Infant
Infant, Newborn
Intelligence
Male
Memory
Mental Health
Mental Processes
Patient Compliance
Treatment Outcome
jenkins-FCD Prod-468 69a93cef3257f26b866d455c1d2b2d0f28382f14