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Role of the spleen in the transdiaphragmatic spread of Hodgkin's disease. Am J Med 1986 Dec;81(6):959-61

Date

12/01/1986

Pubmed ID

3799656

DOI

10.1016/0002-9343(86)90387-6

Scopus ID

2-s2.0-0023017435 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

Results of detailed staging laparotomy for Hodgkin's disease with supradiaphragmatic presentation in 78 patients showed 28 with subdiaphragmatic involvement. All 28 patients with intra-abdominal disease had splenic involvement. On the basis of findings of this study and published series on staging laparotomy, it is proposed that the spleen is the first site of intra-abdominal disease in this group of patients, and that Hodgkin's disease spreads to the intra-abdominal lymph nodes, liver, and bone marrow from the spleen.

Author List

Mann JL, Hafez GR, Longo WL

Author

Walter L. Longo MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Abdominal Neoplasms
Biopsy
Hodgkin Disease
Humans
Laparotomy
Neoplasm Invasiveness
Neoplasm Staging
Splenectomy
Splenic Neoplasms