Role of the spleen in the transdiaphragmatic spread of Hodgkin's disease. Am J Med 1986 Dec;81(6):959-61
Date
12/01/1986Pubmed ID
3799656DOI
10.1016/0002-9343(86)90387-6Scopus ID
2-s2.0-0023017435 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Results of detailed staging laparotomy for Hodgkin's disease with supradiaphragmatic presentation in 78 patients showed 28 with subdiaphragmatic involvement. All 28 patients with intra-abdominal disease had splenic involvement. On the basis of findings of this study and published series on staging laparotomy, it is proposed that the spleen is the first site of intra-abdominal disease in this group of patients, and that Hodgkin's disease spreads to the intra-abdominal lymph nodes, liver, and bone marrow from the spleen.
Author List
Mann JL, Hafez GR, Longo WLAuthor
Walter L. Longo MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Abdominal NeoplasmsBiopsy
Hodgkin Disease
Humans
Laparotomy
Neoplasm Invasiveness
Neoplasm Staging
Splenectomy
Splenic Neoplasms