Faculty Collaboration Database

Advanced Age Does Not Negatively Impact Health-Related Quality of Life in Inflammatory Bowel Disease. Dig Dis Sci 2018 Jul;63(7):1787-1793

Date

05/02/2018

Pubmed ID

29713985

DOI

10.1007/s10620-018-5076-6

Scopus ID

2-s2.0-85049177455 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

BACKGROUND: Health-related quality of life (HRQoL) is significantly impacted in patients with inflammatory bowel disease (IBD). Many studies have assessed HRQoL in patients of all ages, and few focus on the elderly.

AIM: To determine the influence of advanced age (> 65 years) and age at diagnosis on patients with IBD.

METHODS: This is a retrospective study of prospectively collected data from a single IBD tertiary referral center. Patients had disease activity indices [Harvey-Bradshaw index (HBI), Ulcerative Colitis Disease Activity Index (UCDAI), and Short Inflammatory Bowel Disease Questionnaire (SIBDQ)] recorded during every clinic visit. Three groups of patients: > 65 years, 41-64 years, and < 40 years with > 5 SIBDQ entries were included. Influence of disease type, disease duration, extent of involvement, and comorbidities such as cardiovascular (CV) disease, pulmonary disease, diabetes mellitus (DM), and psychological disorders were noted as confounders. Statistical analysis was performed using ANOVA, Pearson correlation, and logistic regression model.

RESULTS: Disease severity indices significantly affected SIBDQ score in both Crohn's disease (CD) and ulcerative colitis (UC) (p < 0.001 for HBI in CD, p < 0.001 UCDAI in UC). Disease extent (p = 0.011) and psychological disorders (p < 0.001) significantly affected SIBDQ score in CD. Chronological age, age at diagnosis, disease duration, number of clinic visits, CV disease, pulmonary disease, and DM were not significant predictors of SIBDQ score (p > 0.05).

CONCLUSIONS: HRQoL was negatively influenced by disease extent and psychological disorders in CD but not in UC patients. Advanced age was not a predictor of poor HRQoL in both CD and UC.

Author List

Perera LP, Bhandari S, Liu R, Guilday C, Zadvornova Y, Saeian K, Eastwood D

Authors

Sanjay Bhandari MD Assistant Professor in the Medicine department at Medical College of Wisconsin
Corinne Guilday PsyD Instructor in the Neurology department at Medical College of Wisconsin
Kia Saeian MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Age Factors
Aged
Aging
Colitis, Ulcerative
Comorbidity
Crohn Disease
Female
Humans
Male
Middle Aged
Quality of Life
Retrospective Studies
Risk Factors
Severity of Illness Index
Surveys and Questionnaires
Tertiary Care Centers
Wisconsin