A method for age-matched OCT angiography deviation mapping in the assessment of disease- related changes to the radial peripapillary capillaries. PLoS One 2018;13(5):e0197062
Date
05/26/2018Pubmed ID
29795576Pubmed Central ID
PMC5993123DOI
10.1371/journal.pone.0197062Scopus ID
2-s2.0-85047485528 (requires institutional sign-in at Scopus site) 25 CitationsAbstract
PURPOSE: To present a method for age-matched deviation mapping in the assessment of disease-related changes to the radial peripapillary capillaries (RPCs).
METHODS: We reviewed 4.5x4.5mm en face peripapillary OCT-A scans of 133 healthy control eyes (133 subjects, mean 41.5 yrs, range 11-82 yrs) and 4 eyes with distinct retinal pathologies, obtained using spectral-domain optical coherence tomography angiography. Statistical analysis was performed to evaluate the impact of age on RPC perfusion densities. RPC density group mean and standard deviation maps were generated for each decade of life. Deviation maps were created for the diseased eyes based on these maps. Large peripapillary vessel (LPV; noncapillary vessel) perfusion density was also studied for impact of age.
RESULTS: Average healthy RPC density was 42.5±1.47%. ANOVA and pairwise Tukey-Kramer tests showed that RPC density in the ≥60yr group was significantly lower compared to RPC density in all younger decades of life (p<0.01). Average healthy LPV density was 21.5±3.07%. Linear regression models indicated that LPV density decreased with age, however ANOVA and pairwise Tukey-Kramer tests did not reach statistical significance. Deviation mapping enabled us to quantitatively and visually elucidate the significance of RPC density changes in disease.
CONCLUSIONS: It is important to consider changes that occur with aging when analyzing RPC and LPV density changes in disease. RPC density, coupled with age-matched deviation mapping techniques, represents a potentially clinically useful method in detecting changes to peripapillary perfusion in disease.
Author List
Pinhas A, Linderman R, Mo S, Krawitz BD, Geyman LS, Carroll J, Rosen RB, Chui TYAuthor
Joseph J. Carroll PhD Director, Professor in the Ophthalmology and Visual Sciences department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Age Factors
Aged
Aged, 80 and over
Anemia, Sickle Cell
Case-Control Studies
Child
Diabetic Retinopathy
Female
Fluorescein Angiography
Glaucoma, Open-Angle
Humans
Image Interpretation, Computer-Assisted
Male
Middle Aged
Retina
Retinal Vein Occlusion
Retinal Vessels
Tomography, Optical Coherence
