Central Venous Catheter-associated Venous Thromboembolism in Children With Hematologic Malignancy. J Pediatr Hematol Oncol 2018 Nov;40(8):e519-e524
Date
06/05/2018Pubmed ID
29863581DOI
10.1097/MPH.0000000000001229Scopus ID
2-s2.0-85048252637 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
In pediatric oncology, the diagnosis of a hematologic malignancy and presence of a central venous catheter (CVC) have been identified as significant risk factors for the development of a venous thromboembolism (VTE). There remain little data regarding CVC factors associated with CVC-related VTE. Using the VTE and oncology database in a quaternary care center, a retrospective cohort study was conducted in children below 18 years old with hematologic cancer from November 5, 2012 to April 4, 2016. Patient, CVC factors, and VTE occurrence were analyzed to identify significant patient and CVC factors associated with the development of clinically identified CVC-related VTE. Utilizing the χ, Mann-Whitney, and the Fisher exact tests, patient factors were compared across VTE yes/no groups. Of the 198 study patients, 22 VTE cases were identified. Eighteen VTE events were CVC-associated, occurring in 9% of study population. Peripherally inserted central catheter lines and older ages were associated with VTE. The use of tissue-plasminogen activator for CVC occlusion was associated with decreased VTE rates, suggesting a protective potential.
Author List
Onyeama SN, Hanson SJ, Dasgupta M, Baker K, Simpson PM, Punzalan RCAuthors
Rowena C. Punzalan MD Associate Professor in the Pediatrics department at Medical College of WisconsinPippa M. Simpson PhD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdolescentAdult
Central Venous Catheters
Child
Child, Preschool
Female
Follow-Up Studies
Hematologic Neoplasms
Humans
Male
Retrospective Studies
Thromboembolism
Tissue Plasminogen Activator
