Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Central Venous Catheter-associated Venous Thromboembolism in Children With Hematologic Malignancy. J Pediatr Hematol Oncol 2018 11;40(8):e519-e524

Date

06/05/2018

Pubmed ID

29863581

DOI

10.1097/MPH.0000000000001229

Scopus ID

2-s2.0-85048252637   1 Citation

Abstract

In pediatric oncology, the diagnosis of a hematologic malignancy and presence of a central venous catheter (CVC) have been identified as significant risk factors for the development of a venous thromboembolism (VTE). There remain little data regarding CVC factors associated with CVC-related VTE. Using the VTE and oncology database in a quaternary care center, a retrospective cohort study was conducted in children below 18 years old with hematologic cancer from November 5, 2012 to April 4, 2016. Patient, CVC factors, and VTE occurrence were analyzed to identify significant patient and CVC factors associated with the development of clinically identified CVC-related VTE. Utilizing the χ, Mann-Whitney, and the Fisher exact tests, patient factors were compared across VTE yes/no groups. Of the 198 study patients, 22 VTE cases were identified. Eighteen VTE events were CVC-associated, occurring in 9% of study population. Peripherally inserted central catheter lines and older ages were associated with VTE. The use of tissue-plasminogen activator for CVC occlusion was associated with decreased VTE rates, suggesting a protective potential.

Author List

Onyeama SN, Hanson SJ, Dasgupta M, Baker K, Simpson PM, Punzalan RC

Authors

Sheila Hanson MD Professor in the Pediatrics department at Medical College of Wisconsin
Rowena C. Punzalan MD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Pippa M. Simpson PhD Chief, Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Central Venous Catheters
Child
Child, Preschool
Female
Follow-Up Studies
Hematologic Neoplasms
Humans
Male
Retrospective Studies
Thromboembolism
Tissue Plasminogen Activator
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a