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Myeloid cell responses after spinal cord injury. J Neuroimmunol 2018 Aug 15;321:97-108

Date

06/30/2018

Pubmed ID

29957394

DOI

10.1016/j.jneuroim.2018.06.003

Scopus ID

2-s2.0-85048529482 (requires institutional sign-in at Scopus site)   45 Citations

Abstract

The past decade has revealed much about the complexity of the local inflammatory response after spinal cord injury (SCI). A major challenge is to distinguish between microglia and monocyte-derived macrophages (MDMs) to determine their phenotype and function. Transcriptome studies have revealed microglia-selective genes but are still limited in scope because many markers are downregulated after injury. Additionally, new genetic reporter mice are available to study microglia and MDMs. There is more evidence now for the plasticity and heterogeneity of microglia and MDMs. We also discuss the role of neutrophils that are the first peripheral cells to enter the injured CNS.

Author List

David S, Kroner A, Greenhalgh AD, Zarruk JG, López-Vales R

Author

Antje Kroner-Milsch MD, PhD Associate Professor in the Neurosurgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Humans
Immunity, Cellular
Macrophages
Microglia
Monocytes
Myeloid Cells
Neutrophils
Spinal Cord Injuries