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Triglyceride-lowering effect of dietary vitamin E in streptozocin-induced diabetic rats. Increased lipoprotein lipase activity in livers of diabetic rats fed high dietary vitamin E. Diabetes 1986 Mar;35(3):278-81

Date

03/01/1986

Pubmed ID

3512338

DOI

10.2337/diab.35.3.278

Abstract

High vitamin E supplementation in the diets of streptozocin-induced diabetic rats eliminates accumulation of lipid peroxides in the plasma and the liver, returns the plasma triglycerides toward normal levels, and increases the activity of lipoprotein lipase. Vitamin E has no effect on the levels of insulin or glucose. These findings suggest that vitamin E increases the total hepatic triglyceride lipase activity by increasing the lipoprotein lipase activity possibly by protecting the membrane-bound lipase against peroxidative damage.

Author List

Pritchard KA Jr, Patel ST, Karpen CW, Newman HA, Panganamala RV

Author

Kirkwood A. Pritchard PhD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Blood Glucose
Diabetes Mellitus, Experimental
Insulin
Lipase
Lipid Peroxides
Lipoprotein Lipase
Liver
Male
Rats
Rats, Inbred Strains
Triglycerides
Vitamin E
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a