Hippocampal differentiation without recognition: an fMRI analysis of the contextual cueing task. Learn Mem 2007 Aug;14(8):548-53
Date
08/11/2007Pubmed ID
17690338Pubmed Central ID
PMC2078244DOI
10.1101/lm.609807Scopus ID
2-s2.0-34548333568 (requires institutional sign-in at Scopus site) 100 CitationsAbstract
A central role of the hippocampus is to consolidate conscious forms of learning and memory, while performance on implicit tasks appears to depend upon other structures. Recently, considerable debate has emerged about whether hippocampal-dependent tasks necessarily entail task awareness. In the contextual cueing task, repetition facilitation is implicit, but impaired in patients with amnesia. Whether the hippocampus alone or other MTL structures are required is unclear. Event-related functional magnetic resonance imaging revealed hippocampal activity that differentiates novel from repeated arrays. This pattern of results was observed without recognition of the repeating arrays. This finding provides support for the claim that the hippocampus is involved in processes outside the domain of conscious learning and memory.
Author List
Greene AJ, Gross WL, Elsinger CL, Rao SMAuthor
William Gross MD, PhD Assistant Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Consciousness
Female
Hippocampus
Humans
Magnetic Resonance Imaging
Male
Memory
Pattern Recognition, Visual
Reaction Time
Temporal Lobe
