Medical College of Wisconsin
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Hippocampal differentiation without recognition: an fMRI analysis of the contextual cueing task. Learn Mem 2007 Aug;14(8):548-53

Date

08/11/2007

Pubmed ID

17690338

Pubmed Central ID

PMC2078244

DOI

10.1101/lm.609807

Scopus ID

2-s2.0-34548333568   95 Citations

Abstract

A central role of the hippocampus is to consolidate conscious forms of learning and memory, while performance on implicit tasks appears to depend upon other structures. Recently, considerable debate has emerged about whether hippocampal-dependent tasks necessarily entail task awareness. In the contextual cueing task, repetition facilitation is implicit, but impaired in patients with amnesia. Whether the hippocampus alone or other MTL structures are required is unclear. Event-related functional magnetic resonance imaging revealed hippocampal activity that differentiates novel from repeated arrays. This pattern of results was observed without recognition of the repeating arrays. This finding provides support for the claim that the hippocampus is involved in processes outside the domain of conscious learning and memory.

Author List

Greene AJ, Gross WL, Elsinger CL, Rao SM

Author

William Gross MD, PhD Assistant Professor in the Anesthesiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Consciousness
Female
Hippocampus
Humans
Magnetic Resonance Imaging
Male
Memory
Pattern Recognition, Visual
Reaction Time
Temporal Lobe