Faculty Collaboration Database

Trends in survival outcomes of B-lineage acute lymphoblastic leukemia in elderly patients: analysis of Surveillance, Epidemiology, and End Results database. Leuk Lymphoma 2015;56(8):2296-300

Date

12/17/2014

Pubmed ID

25495170

DOI

10.3109/10428194.2014.991921

Scopus ID

2-s2.0-84943399527 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

B-lineage acute lymphoblastic leukemia (B-ALL) in the elderly population is generally considered to have a poor prognosis. It is unclear whether their survival has improved in the current era. Using the Surveillance, Epidemiology, and End Results database, we selected 717 elderly patients (age≥60) with B-ALL diagnosed between 1992 and 2011. Overall survival (OS) was compared based on their period of diagnosis and age. Patients in the age group 60-69 had an improvement in OS over time, both 1-year OS (49.4% in 2002-2011 vs. 33.1% in 1992-2001) and 5-year OS (20.4% in 2002-2011 vs. 8.1% in 1992-2001, p=0.002). Patients≥70 years had no significant improvement in 1-year OS or 5-year OS (5-year OS 5.5% in 1992-2001 vs. 9.7% in 2002-2011, p=0.326). Hence, there are discrepancies in the improvement of OS among elderly patients with B-ALL. Further focus of research in elderly patients with B-ALL is needed to improve their outcome.

Author List

Guru Murthy GS, Venkitachalam R, Mehta P

Authors

Guru Subramanian Guru Murthy MD Assistant Professor in the Medicine department at Medical College of Wisconsin
Raji Venkitachalam MBBS Assistant Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Age Factors
Aged
Aged, 80 and over
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Population Surveillance
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Proportional Hazards Models
Risk Factors
SEER Program
United States