Faculty Collaboration Database

Effect of radiotherapy on the survival of patients with stage I and stage II mantle cell lymphoma: analysis of the Surveillance, Epidemiology and End Results database. Clin Lymphoma Myeloma Leuk 2014 Sep;14 Suppl:S90-5

Date

12/10/2014

Pubmed ID

25486963

DOI

10.1016/j.clml.2014.04.013

Scopus ID

2-s2.0-84939427796 (requires institutional sign-in at Scopus site)   15 Citations

Abstract

BACKGROUND: Radiotherapy is a treatment option for stage I and stage II MCL. However, data demonstrating the role of RT in a larger patient population and its real world effects are unknown.

MATERIALS AND METHODS: To demonstrate the role of RT in the OS of patients with stage I and stage II MCL, we performed a retrospective analysis of the SEER database. Included patients were adults with age > 40 years who had MCL stages I and II, and diagnosis between 1992 and 2010. We excluded patients lacking information on demographic characteristics, survival, and RT. Patients were analyzed in 2 groups, those treated with initial RT (RT group) and those not treated with initial RT (no-RT group).

RESULTS: A total of 657 patients were eligible for analysis with 178 patients in the RT group and 479 patients in the no-RT group. The median age of the study group was 68 years. The RT group had a significantly greater proportion of patients with age < 60, male sex, and extranodal disease. Median OS was 103 months in the RT group versus 66 months in the no-RT group (P = .002). On Multivariate analysis, treatment with initial RT was associated with a lower hazard for mortality (hazard ratio, 0.767; 95% confidence interval, 0.602-0.979; P = .033). Age < 60, stage I disease, and extranodal disease were independently associated with a significantly decreased hazard for mortality on Multivariate analysis.

CONCLUSION: Although stage I and stage II MCL constitute only a small proportion of this disease, our study demonstrates that upfront RT improves the OS of these patients.

Author List

Guru Murthy GS, Venkitachalam R, Mehta P

Authors

Guru Subramanian Guru Murthy MD Assistant Professor in the Medicine department at Medical College of Wisconsin
Raji Venkitachalam MBBS Assistant Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Female
Humans
Lymphoma, Mantle-Cell
Male
Middle Aged
Neoplasm Staging
Population Surveillance
Retrospective Studies
SEER Program
Treatment Outcome