Clot strength is negatively associated with ambulatory function in patients with peripheral artery disease and intermittent claudication. Angiology 2015 Apr;66(4):354-9
Date
04/30/2014Pubmed ID
24778425Pubmed Central ID
PMC4415160DOI
10.1177/0003319714532518Scopus ID
2-s2.0-84927514091 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Peripheral artery disease (PAD) is associated with exercise impairment and greater thrombotic risk. We investigated whether clot formation and platelet aggregation assessed by thromboelastography and light-transmission aggregometry correlate with the severity of symptomatic PAD assessed by ambulatory function measures. We studied 40 symptomatic patients with PAD in whom severity of disease was assessed using ankle-brachial index, peak walking time (PWT), claudication onset time, peak oxygen uptake, daily ambulatory activity, and walking impairment questionnaire (WIQ) scores. Clot strength correlated negatively with peak oxygen uptake, PWT, WIQ distance, and stair-climbing scores. Time to clot formation did not correlate with exercise parameters. Platelet aggregation was negatively correlated with WIQ distance score and was positively correlated with PWT and peak oxygen uptake. In conclusion, clot strength and platelet aggregation correlated with objective and self-perceived ambulatory measures. Patients with PAD having more severe walking impairment may be likely to form stronger clots.
Author List
Mauer K, Gardner AW, Dasari TW, Stoner JA, Blevins SM, Montgomery PS, Saucedo JF, Exaire JEAuthor
Jorge Saucedo MD Chief, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Ankle Brachial Index
Blood Coagulation
Cross-Sectional Studies
Exercise Test
Exercise Tolerance
Female
Humans
Intermittent Claudication
Male
Middle Aged
Mobility Limitation
Oklahoma
Oxygen Consumption
Peripheral Arterial Disease
Platelet Aggregation
Platelet Function Tests
Predictive Value of Tests
Prognosis
Prospective Studies
Severity of Illness Index
Surveys and Questionnaires
Time Factors
Walking
