Faculty Collaboration Database

In-hospital and 1-year outcomes with drug-eluting versus bare metal stents in saphenous vein graft intervention: a report from the EVENT registry. Catheter Cardiovasc Interv 2012 Dec 01;80(7):1127-36

Date

03/21/2012

Pubmed ID

22431166

DOI

10.1002/ccd.24352

Scopus ID

2-s2.0-85027921635 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

OBJECTIVES: To compare outcomes of patients receiving drug-eluting stents (DES) versus bare metal stents (BMS) during percutaneous coronary intervention (PCI) of saphenous vein bypass grafts (SVG).

BACKGROUND: Long-term benefits of DES versus BMS are well established for native vessel PCI. Benefit in patients undergoing SVG intervention is less certain. We used data from a multicenter registry (evaluation of drug eluting stents and ischemic events, EVENT) to compare outcomes among patients treated with DES versus BMS 1-year following SVG interventions.

METHODS: Between July 2004 and December 2007, 684 patients in EVENT underwent SVG PCI (515 DES only, 169 BMS only). The primary endpoint was a composite of death, myocardial infarction (MI), and target lesion revascularization between hospital discharge and 1-year follow-up. Propensity score stratification was used to adjust for differences between groups.

RESULTS: Baseline demographic and clinical characteristics of patients treated with DES and BMS were similar. The DES group had fewer men and a higher prevalence of prior PCI. Patients receiving DES had less angiographic thrombus, less frequent use of embolic protection devices, greater total stent length, and smaller maximum stent diameters. Unadjusted outcomes between discharge and 1-year follow-up did not differ between the groups. After risk adjustment, the primary outcome was less frequent among patients treated with DES (adjusted HR = 0.48, 95% CI = 0.27-0.84, P < 0.01) with similar relative benefits across the individual endpoints.

CONCLUSIONS: Among patients undergoing SVG PCI in a "real world" registry analyzed using propensity score stratification, treatment with DES compared with BMS was associated with reduced MACE at 1 year following PCI.

Author List

Tolerico PH, Cohen DJ, Kleiman NS, Berger PB, Brilakis ES, Piana RN, Shammo S, Keyes MJ, Kennedy KF, Massaro JM, Saucedo JF, EVENT Investigators

Authors

Jorge Saucedo MD Chief, Professor in the Medicine department at Medical College of Wisconsin
Salim Shammo MD Staff Physician in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Chi-Square Distribution
Coronary Artery Bypass
Drug-Eluting Stents
Embolic Protection Devices
Female
Graft Occlusion, Vascular
Humans
Male
Metals
Middle Aged
Myocardial Infarction
Percutaneous Coronary Intervention
Propensity Score
Prospective Studies
Prosthesis Design
Registries
Risk Assessment
Risk Factors
Saphenous Vein
Stents
Thrombosis
Time Factors
Treatment Outcome
United States