Faculty Collaboration Database

Endothelial cell perturbation and low-density lipoprotein. Quantitative autoradiography. Ann N Y Acad Sci 1987;516:412-7

Date

01/01/1987

Pubmed ID

3439738

DOI

10.1111/j.1749-6632.1987.tb33060.x

Scopus ID

2-s2.0-0023613845 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

The focal entry and accumulation of LDL within the arterial wall of the normal animal may represent an early stage in the development of the atherosclerotic plaque. Concentrations of LDL 10 to 100 times normal medial concentrations might be difficult to clear from the arterial wall, permitting accumulation of lipid. Elevated LDL concentrations, in proximity to smooth muscle cells, appear to stimulate SMC proliferation. High LDL concentrations might also enhance mononuclear cell adhesion to endothelium. Since LDL has a high affinity for heparin and heparin for growth factors, LDL accumulation may be a mechanism for the concentration of such materials in the intima. The observation of markedly enhanced macromolecular permeability foci could be related to several potential mechanisms of initiation of atherosclerosis. This observation is of particular note when the focal occurrence of atherosclerosis is considered. Although atherosclerosis is seen as a generalized thickening of the intima, it is the focal narrowing of the lumen that is often responsible for the stenosis which produces symptoms such as angina or myocardial infarction.

Author List

Morrel EM, Holland JA, Pritchard KA, Colton CK, Stemerman MB

Author

Kirkwood A. Pritchard PhD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Aorta, Abdominal
Arteriosclerosis
Autoradiography
Cells, Cultured
Endothelium, Vascular
Horseradish Peroxidase
Iodine Radioisotopes
Lipoproteins, LDL
Rabbits