RNA processing control in avian retroviruses. Front Biosci 2008 May 01;13:3869-83
Date
05/30/2008Pubmed ID
18508481Pubmed Central ID
PMC2575692DOI
10.2741/2975Scopus ID
2-s2.0-42649114510 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Upon integration into the host chromosome, retroviral gene expression requires transcription by the host RNA polymerase II, and viral messages are subject RNA processing events including 5'-end capping, pre-mRNA splicing, and polyadenylation. At a minimum, RNA splicing is required to generate the env mRNA, but viral replication requires substantial amounts of unspliced RNA to serve as mRNA and for incorporation into progeny virions as genomic RNA. Therefore, splicing has to be controlled to preserve the large unspliced RNA pool. Considering the current view that splicing and polyadenylation are coupled, the question arises as to how genome-length viral RNA is efficiently polyadenylated in the absence of splicing. Polyadenylation of many retroviral mRNAs is inefficient; in avian retroviruses, approximately 15 percent of viral transcripts extend into and are polyadenylated at downstream host genes, which often has profound biological consequences. Retroviruses have served as important models to study RNA processing and this review summarizes a body of work using avian retroviruses that has led to the discovery of novel RNA splicing and polyadenylation control mechanisms.
Author List
McNally MTAuthor
Mark T. McNally PhD Associate Professor in the Microbiology and Immunology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AlpharetrovirusRNA Precursors
RNA Processing, Post-Transcriptional
RNA Splicing
RNA, Messenger
RNA, Viral
Rous sarcoma virus
