Acquisition, Persistence, and Clearance of Human Papillomavirus Infection Among Male Virgins Residing in Brazil, Mexico, and the United States. J Infect Dis 2018 Feb 14;217(5):767-776
Date
11/23/2017Pubmed ID
29165581Pubmed Central ID
PMC5853496DOI
10.1093/infdis/jix588Scopus ID
2-s2.0-85044532825 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
BACKGROUND: Little is known about the natural history of human papillomavirus (HPV) infection in male virgins. This study estimated the incidence and clearance of genital HPV infection and the factors associated with these measures among men who denied at baseline ever having penetrative sex.
METHODS: A cohort of 4123 men residing in Brazil, Mexico, and the United States were followed every 6 months for up to 10 visits. Genital exfoliated cells were collected and genotyped for 36 HPV types. Eighty-seven men were classified as virgins and included for analysis. Cox proportional hazards models identified factors associated with the incidence and clearance of genital HPV infection.
RESULTS: The incidence rates for any HPV infection among virgins who did and those who did not initiate sex during follow-up were 26.2 and 14.6 cases/1000 person-months, respectively. After penetrative sex initiation, 45.5% of men acquired HPV within 24 months. Younger age, current smoking, no recent female sex partners, and prevalent HPV infection were associated with high-risk HPV clearance.
CONCLUSION: Virgins who did not initiate sex during follow-up still acquired HPV infection, possibly through nonpenetrative sexual contact. Further prospective cohort studies are needed to better understand factors associated with HPV acquisition and clearance in male virgins and recent nonvirgins.
Author List
Liu Z, Nyitray AG, Hwang LY, Swartz MD, Abrahamsen M, Lazcano-Ponce E, Villa LL, Giuliano ARAuthor
Alan Nyitray PhD Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Brazil
Cohort Studies
Genotype
Humans
Incidence
Male
Mexico
Middle Aged
Papillomaviridae
Papillomavirus Infections
Risk Factors
Sexual Behavior
Surveys and Questionnaires
United States
Young Adult
