Household aggregation of Staphylococcus aureus by clonal complex and methicillin resistance profiles in Starr County, Texas. Eur J Clin Microbiol Infect Dis 2017 Oct;36(10):1787-1793
Date
05/06/2017Pubmed ID
28474178DOI
10.1007/s10096-017-2992-xScopus ID
2-s2.0-85018751429 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Staphylococcus aureus is one of the most common causes of skin and soft tissue infections in health-care and community settings, but transmission of S. aureus in community-based populations is incompletely understood. S. aureus carriage phenotypes (persistent, intermittent, and non-carriers) were determined for households from Starr County, TX. Nasal swabs were collected from a cohort of 901 residents and screened for the presence of S. aureus. Isolated strains were spa-typed and assigned to clonal complexes. Of the 901 participants there were 134 pairs, 28 trios, 11 quartets, 3 quintets and 1 septet residing in the same household. There was a significant increase in "ever" carriers (persistent and intermittent carriers combined) in these households over that expected based on population frequencies (p = 0.029). There were 42 ever carrier pairs of individuals with 21 concordant for clonal complex type whereas only 4.7 were expected to be so (p = 6.9E-11). These results demonstrated clear aggregation of S. aureus carriage and concordance for strain types within households. As antibiotic-resistant S. aureus strains increase in community settings, it is important to better understand risk factors for colonization, mechanisms of transmission, clonal complexes present, and the role of household concordance/transmission.
Author List
Hanis CL, Garrett KE, Essigmann HT, Robinson DA, Gunter SM, Nyitray AG, Brown ELAuthor
Alan Nyitray PhD Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Aged, 80 and over
Carrier State
Family Characteristics
Family Health
Female
Genotype
Humans
Male
Methicillin Resistance
Middle Aged
Molecular Epidemiology
Molecular Typing
Prospective Studies
Staphylococcal Infections
Staphylococcus aureus
Texas
Young Adult
