Comparison of anal HPV natural history among men by country of residence: Brazil, Mexico, and the United States. J Infect 2017 Jul;75(1):35-47
Date
04/02/2017Pubmed ID
28363585Pubmed Central ID
PMC6640845DOI
10.1016/j.jinf.2017.03.010Scopus ID
2-s2.0-85017094195 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
OBJECTIVES: Globally, anal cancer incidence is rare, but is increasing in some world regions. Our objective was to assess differences in anal HPV natural history in three countries.
METHODS: Men aged 18-70 years were recruited from the US (n = 634), Mexico (n = 665), and Brazil (n = 731). Anal specimens were collected every six-months. HPV genotyping was assessed by Linear Array. Anal HPV prevalence was compared using the Fisher's exact test. HPV infection incidence rates (IR) and 95% confidence intervals (CI) were calculated.
RESULTS: Any anal HPV prevalence was highest among men from Brazil (24%) compared to Mexico (15%) and the US (15%). When stratified by sexual history, the prevalence of any HPV among MSM/MSMW was 43%, 37%, and 45% and 9%, 12%, and 10% for MSW from Brazil, Mexico, and US, respectively. Any HPV incidence was significantly higher among men from Brazil compared to US men (IRR = 2.4, 95% CI = 1.7-3.4) and comparable between men from Mexico and the US (IRR = 1.2, 95% CI = 0.8-1.8).
CONCLUSION: Men in Brazil and Mexico often have similar, if not higher incidence of anal HPV compared to men from the U.S., and may benefit from gender neutral HPV vaccine policies.
Author List
Sudenga SL, Nyitray AG, Torres BN, Silva R, Villa L, Lazcano-Ponce E, Abrahamsen M, Baggio ML, Salmeron J, Quiterio M, Giuliano ARAuthor
Alan Nyitray PhD Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Anal Canal
Anus Diseases
Brazil
HIV Infections
Heterosexuality
Homosexuality, Male
Humans
Male
Mexico
Middle Aged
Papillomaviridae
Papillomavirus Infections
Papillomavirus Vaccines
Prevalence
Risk Factors
Sexual Behavior
United States
Young Adult
