Faculty Collaboration Database

Analysis of persistence of human papillomavirus infection in men evaluated by sampling multiple genital sites. Eur Rev Med Pharmacol Sci 2015 Nov;19(21):4153-63

Date

11/26/2015

Pubmed ID

26592842

Scopus ID

2-s2.0-84958156540 (requires institutional sign-in at Scopus site)   33 Citations

Abstract

OBJECTIVE: Although human papillomavirus (HPV) infection has been studied extensively in women, data on male infection are limited. The purpose of this study was to investigate persistence of HPV infection at multiple genital sites in men and to define potential associations with socio-behavioural characteristics.

PATIENTS AND METHODS: Penile, urethral and seminal specimens were tested by the INNO-LiPA HPV system (Innogenetics) and a PCR assay. Persistence was defined as the detection of same HPV type at ≥ 2 consecutive visits. The Kaplan-Meier method and the log-rank test were applied to estimate the likelihood of persistence.

RESULTS: A total of 50 men (median age: 33 years) were followed for a median of 14.7 months. Altogether, 49%, 36%, 26% and 11% of baseline HPV-positive men had 6-, 12-, 18- and 24-month persistent infection with any HPV type, respectively. The 6-, 12- and 18- month persistence was more common for oncogenic HPV infections; 24-month persistence was similar. The median duration of persistence was 21.7 months for any HPV. The median duration of persistence for any HPV type was significantly longer in the penile sample (22.5 months, 95% CI: 18.3-26.7) than the semen sample (15.3 months, 95% CI: 14.5-16.1).

CONCLUSIONS: Over a third of type-specific HPV infections in men remained persistent over a 24-month period. The median duration of HPV infection was longer in penile samples compared to seminal samples. As being increasing the attention of HPV vaccination as a potential preventive approach also for men, it is imperative to obtain additional insight on natural history of HPV infection in men, particularly as far as incidence and duration are concerned.

Author List

Capra G, Nyitray AG, Lu B, Perino A, Marci R, Schillaci R, Matranga D, Firenze A, Caleca M, Bellavia C, Guarneri F, Giuliano A, Giovannelli L

Author

Alan Nyitray PhD Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Cohort Studies
Female
Genotype
Humans
Male
Middle Aged
Papillomaviridae
Papillomavirus Infections
Penis
Polymerase Chain Reaction
Semen
Specimen Handling
Urethra
Young Adult