Faculty Collaboration Database

The role of monogamy and duration of heterosexual relationships in human papillomavirus transmission. J Infect Dis 2014 Apr 01;209(7):1007-15

Date

11/21/2013

Pubmed ID

24253288

Pubmed Central ID

PMC3952669

DOI

10.1093/infdis/jit615

Scopus ID

2-s2.0-84898977305 (requires institutional sign-in at Scopus site)   34 Citations

Abstract

BACKGROUND:  Published data are equivocal about the relative rates of male-to-female and female-to-male human papillomavirus (HPV) transmission. Our objective was to estimate genital HPV incidence among heterosexual partners from a broad age range and to investigate the effects of monogamy and relationship duration on incidence.

METHODS:  HPV genotyping was conducted for heterosexual partners, aged 18-70 years, from Tampa, Florida, who provided genital exfoliated cell specimens at semiannual visits during a 2-year study. The rate of incident HPV detection was assessed for 99 couples, and transmission incidence was estimated among a subset of 65 discordant couples. We also evaluated the effect of monogamy and relationship duration on transmission incidence.

RESULTS:  Couples were followed up for a median of 25 months and had a mean age of 33 years for both sexes. The HPV type-specific transmission incidence rate was 12.3 (95% confidence interval, 7.1-19.6) per 1000 person-months for female-to-male transmission and 7.3 (95% confidence interval, 3.5-13.5) per 1000 person-months for male-to-female transmission. Regardless of monogamy status or relationship duration, there was a similar pattern of increased incident HPV detection among men compared with women.

CONCLUSIONS:  HPV may be transmitted more often from women to men than from men to women, suggesting a need for prevention interventions, such as vaccination, for men.

Author List

Nyitray AG, Lin HY, Fulp WJ, Chang M, Menezes L, Lu B, Abrahamsen M, Papenfuss M, Gage C, Galindo CM, Giuliano AR

Author

Alan Nyitray PhD Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Female
Florida
Genotype
Humans
Incidence
Male
Middle Aged
Papillomaviridae
Papillomavirus Infections
Prospective Studies
Sexual Behavior
Young Adult