Faculty Collaboration Database

The Hybrid Transoral-Pharyngotomy Approach to Oropharyngeal Carcinoma: Technique and Outcome. Ann Otol Rhinol Laryngol 2017 May;126(5):357-364

Date

02/17/2017

Pubmed ID

28205447

Pubmed Central ID

PMC9044482

DOI

10.1177/0003489417691297

Scopus ID

2-s2.0-85018221908 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

BACKGROUND: The indications, techniques, and outcomes for a minimally invasive surgical approach in oropharyngeal squamous cell carcinoma (OPSCC) unsuitable for transoral resection are not well-described.

METHODS: A retrospective case series was performed using a prospectively assembled database of transoral surgery-treated OPSCC patients who also underwent a "hybrid" approach of combined transoral and limited pharyngotomy for tumor resection. Disease and functional outcomes were evaluated.

RESULTS: Twenty patients underwent complete tumor resection using the hybrid approach. Median follow-up was 48 months. No postoperative pharyngocutaneous fistula occurred. One patient (5%) had a local recurrence. Kaplan-Meier estimates for disease-specific survival at 2 and 5 years were 94.4% (95% CI, 84%-100%) and 87% (95% CI, 70%-100%). All but 1 patient (due to chemoradiotherapy-related chondroradionecrosis) were decannulated, and 2 required long-term gastrostomy.

CONCLUSION: In the absence of a favorable transoral access, the "hybrid" approach of combined transoral and limited pharyngotomy can accomplish margin-negative primary tumor resection, with a high degree of disease control and functional recovery in selected OPSCC patients.

Author List

Sinha P, Pipkorn P, Zenga J, Haughey BH

Author

Joseph Zenga MD Assistant Professor in the Otolaryngology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Carcinoma, Squamous Cell
Female
Humans
Laser Therapy
Male
Middle Aged
Minimally Invasive Surgical Procedures
Mouth
Neck Dissection
Neoplasm Recurrence, Local
Neoplasm Staging
Oropharyngeal Neoplasms
Pharyngectomy
Pharynx
Recovery of Function
Retrospective Studies
United States