Metastatic Cancer to the Larynx: A Case Report and Update. J Voice 2016 Nov;30(6):774.e9-774.e12
Date
01/09/2016Pubmed ID
26743607DOI
10.1016/j.jvoice.2015.11.017Scopus ID
2-s2.0-84952065639 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
OBJECTIVE: The aim of this study was to describe a case of colorectal carcinoma metastatic to the larynx and provide a review of the current literature.
METHODS: A case report with chart review was performed. A review of the current literature was performed by systematically searching PubMed, OVID, CINAHL Plus, and EMBASE.
RESULTS: In 1988, a comprehensive literature review identified melanoma as the most common neoplasm to exhibit laryngeal involvement. Since that study, 41 subsequent cases have been reported, and among these, colorectal adenocarcinoma was the most frequent distant primary (24%). In 25 (58%) cases, curative surgery was attempted, but only 4 patients remained disease-free at last follow up. We report the history of a 52-year-old man who presented with rectal adenocarcinoma metastatic to his larynx 4 years after definitive treatment of the primary site.
CONCLUSIONS: In patients with a laryngeal mass and a history of colorectal cancer, or those at high risk of having an occult colorectal primary, metastatic spread to the larynx must always be considered. Although secondary laryngeal metastasis portends a poor prognosis, for the select patient, surgical intervention can provide long-term disease control.
Author List
Zenga J, Mehrad M, Bradley JPAuthor
Joseph Zenga MD Assistant Professor in the Otolaryngology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdenocarcinomaBiopsy
Chemoradiotherapy
Colorectal Neoplasms
Humans
Laryngeal Neoplasms
Male
Middle Aged
Palliative Care
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
