Faculty Collaboration Database

Cross-Sectional Study of four Serological Bone Turnover Markers for the Risk Assessment of Medication-Related Osteonecrosis of the Jaw. J Craniofac Surg 2018 Mar;29(2):e137-e140

Date

12/08/2017

Pubmed ID

29215447

DOI

10.1097/SCS.0000000000004224

Scopus ID

2-s2.0-85044242608 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

BACKGROUND: Despite the benefits related to the use of bisphosphonates and denosumab, medication-related osteonecrosis of the jaw (MRONJ) is a serious complication. The purpose of this study was to investigate the utility of 4 biochemical markers including serum c-terminal telopeptide cross-link of type I collagen (s-CTX), serum osteocalcin (s-OC), serum parathormon (s-PTH), and serum bone-specific alkaline phosphatase (s-BAP) as useful clinical tools to help assess the risk for MRONJ prior to invasive oral surgery.

MATERIALS AND METHODS: Twenty patients diagnosed with MRONJ and 20 controls who have been on antiresorptive therapies with no occurrence of MRONJ were included in this 2-arm cross-sectional study. The s-CTX, s-OC, s-PTH, and s-BAP values were measured. Mann-Whitney U test compared the s-CTX, s-OC, s-PTH, and s-BAP values of the MRONJ group and the controls (P < 0.05).

RESULTS: Lower values were observed in the MRONJ group compared with the control group for s-CTX (130.00 pg/mL versus 230.0 pg/mL; P = 0.12) and for s-OC (10.6 ng/mL versus 14.80 ng/mL; P = 0.051) both without significance and for s-BAP (0.23 μkat/L versus 0.31 μkat/L; P = 0.002) with significance. By contrast, the median s-PTH value of the MRONJ group was higher (30.65 ng/L versus 25.50 ng/L; P = 0.89), but without significance.

CONCLUSIONS: The evaluation of the 4 biochemical markers showed that only the value of s-BAP was significantly decreased in the MRONJ patients compared with the controls. Presently, because of the lack of evidence, a routine check prior to oral surgery for the risk assessment of MRONJ cannot be recommended.

Author List

Peisker A, Raschke GF, Fahmy MD, Guentsch A, Roshanghias K, König KC, Schultze-Mosgau S

Author

Arndt Geuntsch in the CTSI department at Medical College of Wisconsin - CTSI

MESH terms used to index this publication - Major topics in bold

Aged
Aged, 80 and over
Alkaline Phosphatase
Biomarkers
Bisphosphonate-Associated Osteonecrosis of the Jaw
Bone Density Conservation Agents
Bone Remodeling
Collagen Type I
Cross-Sectional Studies
Denosumab
Diphosphonates
Female
Humans
Male
Middle Aged
Osteocalcin
Parathyroid Hormone
Peptides
Risk Assessment