Faculty Collaboration Database

Variables of host response in saliva of patients with periodontitis: a pilot study. Quintessence Int 2012 Sep;43(8):e104-14

Date

10/05/2012

Pubmed ID

23034426

Scopus ID

2-s2.0-84886803943 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

OBJECTIVE: Periodontitis is an infection that results from an imbalance between periodontopathic microorganisms and the local and systemic host defense. This study analyzed saliva samples of patients with periodontitis for several biomarkers of host response.

METHOD AND MATERIALS: Saliva was collected from 13 patients with chronic periodontitis, seven patients with aggressive periodontitis, and 13 periodontally healthy control subjects. Diverse markers of host response representing innate and adaptive immune response as well as antioxidative variables were determined.

RESULTS: Patients with aggressive periodontitis had significantly higher values of lipid peroxidation and cathepsin C activity in saliva. The highest activities of neutrophil elastase, proteinase 3, and superoxide dismutase were measured in chronic periodontitis patients. Levels of antimicrobial peptides HNPs 1-3 were significantly highest in chronic periodontitis patients than in aggressive periodontitis or control subjects. Immunoglobulin G levels directed against Aggregatibacter actinomycetemcomitans were highest in aggressive periodontitis patients, while those directed against Porphyromonas gingivalis were highest in chronic periodontitis patients. Immunoglobulin A levels directed against these periodontopathogens did not differ among the groups.

CONCLUSION: Chronic periodontitis patients showed higher levels of markers primarily associated with combating infection. The levels of markers known mainly for tissue damage were higher in aggressive periodontitis patients. Neutrophil-related markers may be able to identify and differentiate patients with periodontitis.

Author List

Guentsch A, Hiese I, Puklo M, Kiehntopf M, Pfister W, Eick S

Author

Arndt Geuntsch in the CTSI department at Medical College of Wisconsin - CTSI

MESH terms used to index this publication - Major topics in bold

Adaptive Immunity
Adult
Aggregatibacter actinomycetemcomitans
Aggressive Periodontitis
Antibodies, Bacterial
Biomarkers
Case-Control Studies
Cathepsin C
Chronic Periodontitis
Diagnosis, Differential
Female
Humans
Immunity, Innate
Immunoglobulin A
Immunoglobulin G
Leukocyte Elastase
Lipid Peroxidation
Male
Middle Aged
Myeloblastin
Neutrophils
Peroxidase
Pilot Projects
Porphyromonas gingivalis
Saliva
Superoxide Dismutase
alpha-Defensins