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Paraneoplastic cerebellar degeneration in ovarian carcinoma: case report with review of immune modulation. Int J Gynecol Cancer 2008;18(6):1364-7

Date

01/26/2008

Pubmed ID

18217973

DOI

10.1111/j.1525-1438.2007.01173.x

Scopus ID

2-s2.0-40749152616 (requires institutional sign-in at Scopus site)   15 Citations

Abstract

Paraneoplastic cerebellar degeneration (PCD) is a rare nonmetastatic complication of a carcinoma. It is typically mediated by antibodies generated against tumor antigens. These antigens are the same proteins as expressed on Purkinje cells within the cerebellum; immune activation in the central nervous system (CNS) results in the syndrome. A 56-year-old woman with stage IIIC serous ovarian carcinoma diagnosed 3 years prior developed progressive limb ataxia. Serum anti-Yo antibodies were positive, confirming the diagnosis of PCD. Treatment with plasmaphoresis, intravenous immune globulin, and immune modulation with corticosteroids and tacrolimus was unsuccessful. Although the syndrome can be debilitating and treatment options are limited, it may also be an example of a successful host immune response in certain cases.

Author List

Bradley WH, Dottino PR, Rahaman J

Author

William H. Bradley MD Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Female
Humans
Immunotherapy
Middle Aged
Ovarian Neoplasms
Paraneoplastic Cerebellar Degeneration
Review Literature as Topic