Faculty Collaboration Database

Effects of taurodeoxycholate on in vivo water and solute transport in rat jejunum in absence and presence of calcium. Am J Physiol 1986 Feb;250(2 Pt 1):G248-51

Date

02/01/1986

Pubmed ID

3082215

DOI

10.1152/ajpgi.1986.250.2.G248

Scopus ID

2-s2.0-0022443331 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

Bile acids and fatty acids enhance the permeability of brush-border membrane vesicles for calcium. It has been postulated that increased influx of calcium into the enterocyte might be responsible for the fluid secretion induced by dihydroxy bile acids and fatty acids. During in vivo perfusion studies of the rat jejunum, 15 mM taurodeoxycholate induced secretion of electrolytes and water (P less than 0.001), reduced glucose absorption (P less than 0.001), and enhanced the absorption of mannitol (P less than 0.0125) and calcium (P less than 0.001). Calcium absorption continued to be enhanced during perfusion of a CaCl2-containing solution following the perfusion with taurodeoxycholate (P less than 0.05). In view of the previously demonstrated enhanced permeability of the apical brush-border membrane in the presence of bile acids, it is very likely that some calcium enters the enterocyte along the steep concentration gradient in the presence of taurodeoxycholate. In spite of enhanced calcium absorption, 15 mM CaCl2 had no effect on control absorption rates or on fluid secretion induced by taurodeoxycholate. The data indicate that the effects of bile acids on intestinal transport are not mediated by an influx of calcium into the enterocyte.

Author List

Ammon HV, Cho DS, Loeffler RL, Reetz KL

Author

Helmut V. Ammon MD Adjunct Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Absorption
Animals
Bile Acids and Salts
Biological Transport
Calcium
Deoxycholic Acid
Jejunum
Male
Mannitol
Rats
Rats, Inbred Strains
Solutions
Taurodeoxycholic Acid
Water