Effects of lysophosphatidylcholine on jejunal water and solute transport in the rat in vivo. Lipids 1983 Jun;18(6):428-33
Date
06/01/1983Pubmed ID
6877048DOI
10.1007/BF02535429Scopus ID
2-s2.0-0020567176 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
The effects of lysophosphatidylcholine on jejunal water and solute transport were studied in vivo in the rat. Five mM lysophosphatidylcholine significantly reduced absorption of water, electrolytes and glucose (P less than 0.05) and 10 mM lysophosphatidylcholine induced net fluid secretion. The effects of 10 mM lysophosphatidylcholine were significantly reduced in the presence of 5 mM phosphatidylcholine (P less than 0.05) and 2 mM cholesterol (P less than 0.05). The fractional absorption of lysophosphatidylcholine decreased with increasing concentration of the detergent in the perfusion solution. Increasing concentrations of taurocholate in the perfusion solutions potentiated the effects of lysophosphatidylcholine (P less than 0.01), although 10 mM taurocholate by itself had no significant effect on intestinal water and electrolyte transport. The data establish that lysophosphatidylcholine, a zwitterionic detergent, affects intestinal transport in the same way as bile acids, fatty acids and synthetic cationic or nonionic detergents. By comparison with the response of the human jejunum to taurodeoxycholate, it is likely that lysophosphatidylcholine generated during the normal process of digestion has an effect on intestinal water and solute transport in man.
Author List
Ammon HV, Loeffler RE, Luedtke LAAuthor
Helmut V. Ammon MD Adjunct Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBody Water
Intestinal Absorption
Jejunum
Kinetics
Lysophosphatidylcholines
Male
Phosphatidylcholines
Rats
Rats, Inbred Strains
