Effect of glucose on jejunal water and solute absorption in the presence of glycodeoxycholate and oleate in man. Dig Dis Sci 1981 Aug;26(8):710-7
Date
08/01/1981Pubmed ID
7261835DOI
10.1007/BF01316860Scopus ID
2-s2.0-0019521013 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Jejunal perfusion studies were performed in 12 healthy volunteers to study the effects of 14 and 56 mM glucose on fluid secretion induced by 5 mM glycodeoxycholate on 7 mM oleate. Glucose enhanced water absorption under control conditions and reduced water secretion induced by glycodeoxycholate or oleate (P less than 0.01). As has been observed previously, glycodeoxycholate and oleate inhibited glucose absorption (P less than 0.001) and significant linear relationships existed between net water movement and glucose absorption. Glycodeoxycholate also reduced the absorption of 14 mM arabinose (P less than 0.05) and oleate reduced the absorption of 56 mM mannitol (P less than 0.05). Reduced solute absorption in the presence of glycodeoxycholate and oleate, therefore, cannot be attributed to an effect on active transport alone. The relationships between sodium transport and water absorption varied with the glucose concentration in the perfusion solutions. Similarly, the relationships between glucose absorption and sodium absorption varied with glucose concentration. The data suggest that a significant amount of glucose can be absorbed without concomitant absorption of sodium. The data indicate that glucose absorption can stimulate water absorption directly without the mediation of sodium and that water movement follows glucose at a rate which maintains isotonicity.
Author List
Brown BD, Ammon HVAuthor
Helmut V. Ammon MD Adjunct Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
ArabinoseBiological Transport
Deoxycholic Acid
Glucose
Glycodeoxycholic Acid
Humans
Intestinal Absorption
Intestinal Secretions
Male
Mannose
Oleic Acids
Sodium
