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Real time evaluation of tissue optical properties during thermal ablation of ex vivo liver tissues. Int J Hyperthermia 2019 01 01;35(1):176-182



Pubmed ID




Scopus ID

2-s2.0-85052119229   6 Citations


Complete ablation of liver tumors is vital for minimizing the risk of local tumor recurrence. Accurately identifying the hallmarks of tissue necrosis during thermal ablative therapies may significantly increase the efficacy of ablation, while minimizing unnecessary damage to the surrounding normal tissues or critical structures. Light propagation in biological tissues is sensitive to the tissue microstructure and chromophore concentrations. In our previous studies, we found that the wavelength (λ) averaged liver tissue absorption coefficient (µa) and reduced scattering coefficient (µs') change significantly upon heating which may be used for assessment of tissue damage during thermal ablation of solid tumors. Here, we seek to demonstrate the use of an integrated fiber-optic probe for continuous monitoring of the local tissue temperature (T), µa(λ) and µs'(λ) during thermal ablation of ex vivo porcine livers. The wavelength-averaged (435-630 nm) tissue absorption and scattering (µa and µs' ) increased rapidly at 45 °C and plateaued at 67 °C. The mean µa and µs' for liver tissue at 37 °C (n = 10) were 8.5 ± 3.7 and 2.8 ± 1.1 cm-1, respectively. The relative changes in µa and µs' at 37, 55, and 65 °C were significantly different (p < .02) from each other. A relationship between the relative changes in µa and µs' and the degree of tissue damage estimated using the temperature-based Arrhenius model for porcine liver tissues was established and studied.

Author List

Nagarajan VK, Gogineni VR, White SB, Yu B


Venkateswara R. Gogineni PhD Assistant Professor in the Radiology department at Medical College of Wisconsin
Sarah B. White MD, MS, FSIR, FCIRSE Vice Chair, Professor in the Radiology department at Medical College of Wisconsin
Bing Yu PH.D. Assistant Professor of Biomedical Engineering in the Biomedical Engineering department at Marquette University

MESH terms used to index this publication - Major topics in bold

Carcinoma, Hepatocellular
Catheter Ablation
Liver Neoplasms