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Risk Factors Linked to Central Catheter-Associated Thrombosis in Critically Ill Infants in the Neonatal Intensive Care Unit. Am J Perinatol 2019 02;36(3):291-295



Pubmed ID




Scopus ID

2-s2.0-85061501821   1 Citation


OBJECTIVE: Our study identified risk factors for the development of clinically identifiable catheter-associated thrombosis (CT).

STUDY DESIGN: We performed a retrospective cohort study of neonates in whom a central catheter was present. A total of 1,475 catheters were identified in 766 patients during a 36-month study period. The odds ratio (OR) of thrombi formation in catheterized neonates was modeled using simple (single predictor) and multiple (multiple predictors) logistic regressions as well as simple and multiple Cox's proportional hazard models.

RESULT: The incidence of CT was 1.17 per 100 neonates. Unadjusted factors including age at insertion, history of surgery before or during line placement, cholestasis, femoral location, and line size significantly increased the OR or hazards ratio (HR) of developing thrombi formation. In multiple logistic and Cox's regression analyses, three factors continued to be significantly associated with OR or HR of thrombi formation: line size, femoral location, and cholestasis.

CONCLUSION: We conclude that clinically identifiable CT is rare in the neonatal population. Furthermore, catheter-specific characteristics are predictive for CT and require further investigation.

Author List

Lambert I, Tarima S, Uhing M, Cohen SS


Susan Cohen MD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Sergey S. Tarima PhD Associate Professor in the Institute for Health and Equity department at Medical College of Wisconsin
Michael R. Uhing MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Age Factors
Catheterization, Central Venous
Central Venous Catheters
Gestational Age
Infant, Newborn
Intensive Care Units, Neonatal
Logistic Models
Proportional Hazards Models
Retrospective Studies
Risk Factors
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a