Effect of taurine conjugated bile salts with and without lecithin on water and electrolyte transport in the canine gallbladder in vivo. Gastroenterology 1979 Apr;76(4):778-83
Date
04/01/1979Pubmed ID
422005DOI
10.1016/S0016-5085(79)80178-XScopus ID
2-s2.0-0018398382 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
Because dihydroxy bile salts alter water and electrolyte transport in the intestine, we tested the effects of taurine conjugated bile salts on water and electrolyte transport in the canine gallbladder in vivo. 16.7 mM taurodeoxycholate or taurochenodeoxycholate completely abolished net absorption of water (P less than 0.01). 40 mM taurocholate significantly reduced net water absorption (P less than 0.05), whereas 16.7 mM taurocholate had no significant effect. Net movement of electrolytes was closely related to net water movement. Water and electrolyte absorption continued undisturbed when the gallbladders were exposed to 16.7 mM taurodeoxycholate together with 5.6 mM lecithin. Biliary lecithin, therefore, is important for the protection of the mucosa of the gallbladder from the potentially damaging effects of bile salts.
Author List
Ammon HVAuthor
Helmut V. Ammon MD Adjunct Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBile Acids and Salts
Chlorides
Dogs
Electrolytes
Female
Gallbladder
Male
Phosphatidylcholines
Phospholipids
Potassium
Sodium
Taurochenodeoxycholic Acid
Taurocholic Acid
Taurodeoxycholic Acid
Water
