Disseminated CD8-positive, CD30-positive cutaneous lymphoproliferative eruption with overlapping features of mycosis fungoides and primary cutaneous anaplastic large cell lymphoma following remote solitary lesional presentation. J Cutan Pathol 2017 Aug;44(8):703-712
Date
05/13/2017Pubmed ID
28497585DOI
10.1111/cup.12961Scopus ID
2-s2.0-85020482135 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
CD8-positive, CD30-positive cutaneous lymphoproliferative disorders constitute a rare subset of T-cell lymphoproliferative conditions, including variants of primary cutaneous anaplastic large cell lymphoma (ALCL), mycosis fungoides, lymphomatoid papulosis type D, cutaneous gamma-delta T-cell lymphoma and cutaneous peripheral T-cell lymphoma. These entities share overlapping clinical, histopathologic and immunophenotypic features, presenting both a clinical and pathological diagnostic challenge. Presented here is a 73-year-old man with a disseminated, indolent CD30+, CD8+ cutaneous lymphoproliferative disorder with overlapping clinical and histopathological features of both mycosis fungoides and primary cutaneous ALCL, as well as features of lymphomatoid papulosis. To our knowledge, this is the first case of a generalized CD8+, CD30+ eruption with features of both mycosis fungoides and primary cutaneous ALCL arising following an episode of solitary primary cutaneous CD8-positive ALCL.
Author List
Davick JJ, Mutgi KAJ, Wanat KA, Link BK, Liu VAuthor
Karolyn A. Wanat MD Vice Chair, Professor in the Dermatology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedCD8-Positive T-Lymphocytes
Humans
Ki-1 Antigen
Lymphoma, Large-Cell, Anaplastic
Male
Mycosis Fungoides
Neoplasm Proteins
Skin Neoplasms
