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CD30 positive atypical lymphocytes in perniosis: a potential histopathologic pitfall in a benign condition. Am J Dermatopathol 2014 Sep;36(9):730-3

Date

07/30/2014

Pubmed ID

25072680

DOI

10.1097/DAD.0000000000000109

Scopus ID

2-s2.0-84906937174 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

In classical clinical perniosis (chilblains), the presence of atypical lymphocytes with immunohistochemical staining positive for CD30 is unusual and rarely reported. Here we report 2 cases of clinical perniosis, one in a 16-year-old girl and another in a 67-year-old woman. The biopsies revealed lymphocytic infiltrates, papillary dermal edema, and atypical cells highlighted with a CD30 immunohistochemical stain. Our cases demonstrate the importance of clinicopathologic correlation in the assessment of CD30 positive lymphocytes in benign nonneoplastic conditions. Dermatopathologists must be aware of this potential histologic pattern in perniosis to prevent misdiagnosis and overtreatment of this condition.

Author List

Massey PR, Wanat KA, Stewart CL, Kim EJ, Castelo-Soccio L, Elenitsas R, Rubin AI

Author

Karolyn A. Wanat MD Vice Chair, Professor in the Dermatology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Aged
Chilblains
Female
Humans
Ki-1 Antigen
Lymphocytes