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Huntington's Disease: Nuclear Gatekeepers Under Attack. Neuron 2017 Apr 05;94(1):1-4

Date

04/07/2017

Pubmed ID

28384467

DOI

10.1016/j.neuron.2017.03.032

Scopus ID

2-s2.0-85016944880 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

In this issue of Neuron, Gasset-Rosa et al. (2017) and Grima et al. (2017) describe defects in the nuclear pore complex and impaired nucleocytoplasmic transport in Huntington's disease (HD). The findings suggest that erosion of nuclear gatekeeping function, which is found in normal brain aging, may play an important role in the pathogenesis of multiple neurodegenerative disorders, including HD.

Author List

Veldman MB, Yang XW

Author

Matthew B. Veldman PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aging
Brain
Humans
Huntington Disease
Neurons
Nuclear Proteins