Ethanol inhibition of synaptosomal high-affinity choline uptake. Eur J Pharmacol 1988 Jun 22;151(1):51-8
Date
06/22/1988Pubmed ID
3416925DOI
10.1016/0014-2999(88)90691-7Scopus ID
2-s2.0-0023917393 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
Ethanol in vitro inhibited synaptosomal sodium-dependent, high-affinity choline uptake, the rate-limiting step in the synthesis of acetylcholine. This inhibition occurred with ethanol concentrations as low as 50 mM, was reversible and was not attributable to ethanol effects on synaptosomal membrane potential. In contrast, ethanol concentrations as high as 400 mM had no effect on synaptosomal high-affinity uptake of gamma-aminobutyric acid, a major inhibitory neurotransmitter in the central nervous system. The observed ethanol inhibition of choline uptake is consistent with suggestions that depression of cholinergic systems is important in acute ethanol intoxication.
Author List
Mrak RE, North PEAuthor
Paula E. North MD, PhD Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCholine
Ethanol
In Vitro Techniques
Membrane Potentials
Rats
Rats, Inbred Strains
Sodium
Synaptosomes
gamma-Aminobutyric Acid
