Nuts and bolts of 4D-MRI for radiotherapy. Phys Med Biol 2018 Oct 23;63(21):21TR01
Date
10/03/2018Pubmed ID
30272573DOI
10.1088/1361-6560/aae56dScopus ID
2-s2.0-85055175748 (requires institutional sign-in at Scopus site) 102 CitationsAbstract
Magnetic resonance imaging (MRI) is increasingly being used in the radiotherapy workflow because of its superior soft tissue contrast and high flexibility in contrast. In addition to anatomical and functional imaging, MRI can also be used to characterize the physiologically induced motion of both the tumor and organs-at-risk. Respiratory-correlated 4D-MRI has gained large interest as an alternative to 4D-CT for the characterization of respiratory motion throughout the thorax and abdomen. These 4D-MRI data sets consist of three spatial dimensions and the respiratory phase or amplitude over the fourth dimension (opposed to time-resolved 4D-MRI that represents time in the fourth dimension). Over the last 15 years numerous methods have been presented in literature. This review article provides a comprehensive overview of the various 4D-MRI techniques, and describes the differences in MRI data acquisition and 4D data set generation from a methodological point of view. The current status and future perspective of these techniques are highlighted, and the requirements for safe introduction into the clinic (e.g. method validation) are discussed.
Author List
Stemkens B, Paulson ES, Tijssen RHNAuthor
Eric Paulson PhD Chief, Professor in the Radiation Oncology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
HumansImage Processing, Computer-Assisted
Magnetic Resonance Imaging
Movement
Neoplasms
Radiotherapy Planning, Computer-Assisted
Respiratory-Gated Imaging Techniques
