Faculty Collaboration Database

Vitamin D deficiency and electrocardiographic subclinical myocardial injury: Results from National Health and Nutrition Examination Survey-III. Clin Cardiol 2018 Nov;41(11):1468-1473

Date

09/22/2018

Pubmed ID

30239028

Pubmed Central ID

PMC6489797

DOI

10.1002/clc.23078

Scopus ID

2-s2.0-85057048325 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

BACKGROUND: Association of cardiovascular disease (CVD) with nontraditional risk factors such as vitamin D deficiency has been examined previously. An investigation of the association of vitamin D with subclinical myocardial injury (SC-MI) based on an electrocardiographic score is a simple, cost-effective and innovative way to explore this relationship.

HYPOTHESIS: We hypothesize that low vitamin D levels will be associated with prevalent SC-MI independent of traditional CVD risk factors, lifestyle factors, and socioeconomic status.

METHODS: This analysis included 6079 participants (58.3 ± 13.1 years; 54.1% women) without CVD from the third National Health and Nutrition Examination Survey. A multivariable logistic regression model was used to examine the association between vitamin D categories (<20, 20-29, and >30 ng/mL (reference) and cardiac injury score.

RESULTS: There was an incremental increase in the prevalence of SC-MI across vitamin D categories with the highest prevalence in <20 ng/mL, followed by 20 to 29 ng/mL and then >30 ng/mL (trend P-value <0.0001). There was a statistically significant association between vitamin D deficiency (<20 ng/mL) and SC-MI (odds ratio [OR] (95% confidence interval [CI]): 1.27 (1.04-1.55), P = 0.04). This association was stronger in men than women (OR (95% CI): 1.74 (1.32-2.30) vs 0.94 (0.70-1.25) respectively; interaction P-value 0.002).

CONCLUSIONS: Vitamin D deficiency is associated with SC-MI, especially in men. These findings may further highlight the role of nontraditional risk factors in the development of CVD. The value of vitamin D supplementation in the prevention of myocardial ischemia and injury may warrant investigation.

Author List

Ahmad MI, Chevli PA, Li Y, Soliman EZ

Author

Muhammad Imtiaz Ahmad MBBS Assistant Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Biomarkers
Cross-Sectional Studies
Electrocardiography
Female
Heart Diseases
Humans
Life Style
Male
Middle Aged
Nutrition Surveys
Predictive Value of Tests
Prevalence
Risk Factors
Sex Factors
Social Class
United States
Vitamin D
Vitamin D Deficiency