Vasopressin reduces cardiac function and augments cardiopulmonary baroreflex resistance increases in man. J Clin Invest 1986 Apr;77(4):1136-42
Date
04/01/1986Pubmed ID
3514673Pubmed Central ID
PMC424448DOI
10.1172/JCI112413Scopus ID
2-s2.0-0022549988 (requires institutional sign-in at Scopus site) 55 CitationsAbstract
We examined the effects of physiologic infusions of arginine vasopressin (AVP) on cardiovascular hemodynamics and on reflex responses initiated by decreasing cardiopulmonary baroreceptor stimulation (with lower body negative pressure) in 10 healthy, captopril-pretreated young men (19-27 yr). Their responses were compared with those of four volunteers given isosmotic infusion. Heart rate, stroke volume, blood pressure, and forearm blood flow were measured by electrocardiography, impedance cardiography, radial artery cannulation, and strain gauge plethysmography. Two 55-min infusions of AVP at rates of 0.15 and 0.40 ng/kg per min increased average plasma concentrations from control levels of 5 pg/ml to 18 and 36 pg/ml, respectively. These infusions resulted in progressive reductions of heart rate and cardiac output and increases of forearm and total peripheral resistance. Blood pressure increases were significant only during the larger AVP infusion rate. Lower body negative pressure provoked reflex increases of total peripheral resistance. These increases were enhanced 60% during AVP infusion compared with increases during control (pre-AVP). Baseline measurements and reflex responses were unchanged by isosmotic infusions. These results demonstrate that AVP has profound effects on cardiovascular function and augments cardiopulmonary baroreflex-mediated increases of peripheral resistance in man.
Author List
Ebert TJ, Cowley AW Jr, Skelton MAuthors
Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of WisconsinThomas J. Ebert MD, PhD Adjunct Professor in the Anesthesiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdolescentAdult
Arginine Vasopressin
Blood Pressure
Cardiac Output
Catecholamines
Drug Resistance
Electrocardiography
Heart Rate
Hemodynamics
Humans
Male
Plethysmography
Pressoreceptors
Regional Blood Flow
Renin
Stroke Volume
