Effect of AVP on pressor responses to peripheral sympathetic stimulation in the rat. Am J Physiol 1987 Apr;252(4 Pt 2):H675-80
Date
04/11/1987Pubmed ID
3565586DOI
10.1152/ajpheart.1987.252.4.H675Scopus ID
2-s2.0-0023243565 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Studies were carried out to determine whether arginine vasopressin (AVP) could modulate pressor responses to peripheral sympathetic stimulation or potentiate systemic norepinephrine (NE) vasoconstrictor effects. The effects of graded 30-min infusions of AVP (0.02, 0.2, and 2.0 ng X kg-1 X min-1) on the pressor responses to either electrical stimulation of spinal sympathetic outflow or NE injection (0.1, 0.5, and 1.0 micrograms/kg) were determined in central nervous system-ablated rats. Spinal stimulation with increasing frequency (0.25, 0.5, and 1.0 Hz, n = 8) at a constant voltage (20 V) or increasing voltage (8, 10, 15, and 20 V, n = 6) at a constant frequency (1 Hz) elicited significant stimulus-response relationships in mean arterial pressure (MAP). Similarly, NE increased MAP in a dose-related manner. AVP had no significant effect (P less than 0.05) on pressor responses to increasing frequency or voltage stimulation or to NE injection. We conclude that pressor responses to sympathetic stimulation in the rat are not modulated by actions of AVP to inhibit peripheral sympathetic ganglionic transmission or potentiate NE vasoconstrictor effects.
Author List
Osborn JW Jr, Liard JF, Cowley AW JrAuthor
Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsArginine Vasopressin
Blood Pressure
Electric Stimulation
Heart Rate
Male
Norepinephrine
Rats
Spinal Cord
Sympathetic Nervous System
Vasomotor System