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Conversion of aldimines to secondary amines using iron-catalysed hydrosilylation. Org Biomol Chem 2018 Dec 12;16(48):9368-9372

Date

12/06/2018

Pubmed ID

30516772

DOI

10.1039/c8ob01262h

Scopus ID

2-s2.0-85058490576 (requires institutional sign-in at Scopus site)   26 Citations

Abstract

Iron-catalyzed hydrosilylation of imines to amines using a well-defined iron complex is reported. This method employs relatively mild conditions, by reaction of imine, (EtO)3SiH in a 1 : 2 ratio in the presence of 1 mol% precatalyst ([BIAN]Fe(η6-toluene), 3, BIAN = bis(2,6-diisopropylaniline)acenaphthene) at 70 °C. A broad scope of imines was readily converted into the corresponding secondary amines without the need for precatalyst activators.

Author List

Saini A, Smith CR, Wekesa FS, Helms AK, Findlater M

Author

Ann K. Helms MD Professor in the Neurology department at Medical College of Wisconsin