Angiotensin II contributes to blood pressure maintenance in conscious rats treated with yohimbine. Eur J Pharmacol 1988 May 10;149(3):377-80
Date
05/10/1988Pubmed ID
3409962DOI
10.1016/0014-2999(88)90672-3Scopus ID
2-s2.0-0023915554 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Yohimbine (1 mg/kg s.c.) produced significant and persistent increases in plasma renin concentration and plasma norepinephrine concentration in conscious rats, but mean arterial pressure (MAP) and heart rate were unchanged. The subsequent i.v. infusion of the angiotensin II receptor antagonist saralasin (100 micrograms/kg per min) caused a significant decrease (-17%) in MAP. We conclude that yohimbine-induced renin release, and the resultant rise in plasma angiotensin II concentration, prevents the decrease in MAP which would result from the blockade of vascular alpha-adrenoceptors by yohimbine.
Author List
Pfister SL, Keeton TKAuthor
Sandra L. Pfister PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Angiotensin IIAnimals
Blood Pressure
Heart Rate
Male
Rats
Rats, Inbred Strains
Yohimbine
