Faculty Collaboration Database

Inflammasomes: Emerging Central Players in Cancer Immunology and Immunotherapy. Front Immunol 2018;9:3028

Date

01/12/2019

Pubmed ID

30631327

Pubmed Central ID

PMC6315184

DOI

10.3389/fimmu.2018.03028

Scopus ID

2-s2.0-85059829126 (requires institutional sign-in at Scopus site)   38 Citations

Abstract

Inflammation has an established role in cancer development and progression and is a key player in regulating the entry and exit of immune cells in the tumor microenvironment, mounting a significant impact on anti-tumor immunity. Recent studies have shed light on the role of inflammasomes in the regulation of inflammation with a focus on the subsequent effects on the immunobiology of tumors. To generate strong anti-tumor immunity, cross-talk between innate, and adaptive immune cells is necessary. Interestingly, inflammasome bridges both arms of the immune system representing a unique opportunity to manipulate the role of inflammation in favor of tumor suppression. In this review, we discuss the impact of inflammasomes on the regulation of the levels of inflammatory cytokines-chemokines and the efficacy of immunotherapy response in cancer treatment.

Author List

Karan D

MESH terms used to index this publication - Major topics in bold

Adaptive Immunity
Animals
Antineoplastic Agents, Immunological
Caspases
Cytokines
Disease Models, Animal
Humans
Immunity, Innate
Inflammasomes
Inflammation
Lymphocytes, Tumor-Infiltrating
Myeloid Cells
NLR Family, Pyrin Domain-Containing 3 Protein
Neoplasms
Tumor Microenvironment