Effect of dietary vitamin E on the production of platelet 12-hydroxyeicosatetraenoic acid (12-HETE). Thromb Haemost 1986 Feb 28;55(1):6-7
Date
02/28/1986Pubmed ID
3705009Scopus ID
2-s2.0-0022637701 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
Collagen and thrombin challenged platelets from vitamin E-deficient rabbits generated significantly more 12-HETE when compared to the platelets from vitamin E-supplemented rabbits. Similarly, conversion of arachidonic acid to 12-HETE was increased in platelets from vitamin E-deficient rabbits. These data show that vitamin E plays a role not only in deacylation of platelet phospholipids but also in the lipoxygenase mediated reactions.
Author List
Pritchard KA, Greco NJ, Panganamala RVAuthor
Kirkwood A. Pritchard PhD Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
12-Hydroxy-5,8,10,14-eicosatetraenoic AcidAnimals
Blood Platelets
Collagen
Hydroxyeicosatetraenoic Acids
In Vitro Techniques
Male
Rabbits
Thrombin
Vitamin E
Vitamin E Deficiency
